PO-05-079 SMOKING AND THE RISK OF VENTRICULAR TACHYARRHYTHMIAS AMONG IMPLANTABLE CARDIOVERTER DEFIBRILLATOR RECIPIENTS FOR PRIMARY PREVENTION OF SUDDEN CARDIAC DEATH

Smoking has been linked to increased morbidity and mortality in patients with cardiovascular disease. However, limited data exist regarding the arrhythmic effects of smoking at risk for sudden cardiac death (SCD). We aimed evaluate relationship between ventricular tachyarrhythmias SCD. The study population comprised 5,015 implanted an implantable cardioverter defibrillator (ICD) from five landmark randomized ICD trials (MADIT-II, MADIT-CRT, MADIT-RIT, MADIT-RISK, RAID trials). Patients were categorized into three groups based on status time implantation: non-smokers, past smokers, current smokers. primary endpoint was first occurrence tachycardia ≥170 bpm or fibrillation (VT/VF). Secondary endpoints included composite VT/VF SCD inappropriate shocks. A competing analysis carried out using Fine Gray method generate cumulative incidence function (CIF) curves regression models defined endpoints. 5-year a episode higher smokers (32%) than past- (29%) non-smokers (25%) (p=0.009, [Figure, left panel]). Consistent results obtained shocks (10%, 9%, 6%%, respectively; p=0.007, right Multivariate vs. non-smoking associated significant 25% (HR=1.25, p=0.034); corresponding 28% (HR=1.28, p=0.014); 49% (HR=1.49, p=0.03). Conversely, aforementioned not significantly difference past-smokers never-smokers. who smoke implantation experience